第109回薬剤師国家試験

$\tdplotsetmaincoords{15}{-90}\begin{tikzpicture}[scale=1,tdplot_main_coords,rotate=87.5,declare function = {opc=0.9;vdw=1/5; lw=3;Cvdw=1.70 cm; Nvdw=1.55 cm; Ovdw=1.52 cm; Hvdw=1.20 cm; Bvdw=1.92 cm; Clvdw=1.75 cm; Fvdw=1.47 cm;dp=1.700;}]\coordinate (O1) at (1.047, 1.491, 8.411);\coordinate (C2) at (1.178, 2.723, 7.729);\coordinate (H1) at (1.744, 1.342, 8.855);\coordinate (H2A) at (1.280, 3.448, 8.380);\coordinate (H2B) at (0.378, 2.883, 7.185);\coordinate (H2C) at (1.967, 2.693, 7.147);\foreach \labelx /\labely in {O1/H1, C2/H2A, C2/H2B, C2/H2C}\draw[line width = lw, Pink1] (\labelx) -- (\labely);\draw[line width = lw, gray] (O1) -- (C2);\shade[ball color = red, opacity=opc] (O1) circle (vdw*Ovdw);\shade[ball color = black, opacity=opc] (C2) circle (vdw*Cvdw);\foreach \label in {H1, H2A, H2B, H2C}\shade[ball color = white, opacity=opc] (\label) circle (vdw*Hvdw);\end{tikzpicture}$

$\tdplotsetmaincoords{15}{-88.5}\begin{tikzpicture}[scale=1,tdplot_main_coords,declare function = {opc=0.9;a=4.647; b=4.929; c=89.040; alpha=90; beta=90; gamma=90;x0=1.047; y0=1.491; z0=8.411;vdw=2; lw=3;dp=1.700; bp=64.7;}]\coordinate (O1) at (1.047-x0, 1.491-y0, 8.411-z0);\coordinate (C2) at (1.178-x0, 2.723-y0, 7.729-z0);\coordinate (H1) at (1.744-x0, 1.342-y0, 8.855-z0);\coordinate (H2A) at (1.280-x0, 3.448-y0, 8.380-z0);\coordinate (H2B) at (0.378-x0, 2.883-y0, 7.185-z0);\coordinate (H2C) at (1.967-x0, 2.693-y0, 7.147-z0);\draw[line width = lw, gray] (O1) -- (C2);\draw[line width = lw, Pink1] (H1) -- (O1);\draw[line width = lw, Pink1] (C2) -- (H2A);\draw[line width = lw, Pink1] (H2B) -- (C2);\draw[line width = lw, Pink1] (C2) -- (H2C);\shade[ball color = black, opacity=opc] (C2) circle (vdw*1.70 mm);\shade[ball color = red, opacity=opc] (O1) circle (vdw*1.52 mm);\shade[ball color = white, opacity=opc] (H1) circle (vdw*1.20 mm);\shade[ball color = white, opacity=opc] (H2A) circle (vdw*1.20 mm);\shade[ball color = white, opacity=opc] (H2B) circle (vdw*1.20 mm);\shade[ball color = white, opacity=opc] (H2C) circle (vdw*1.20 mm);\node at (O1) [right=2mm] {\tiny $-0.497$};\node at (H1) [right=2mm] {\tiny $+0.293$};\node at (O1) [below=5mm] {\tiny $\rm bp=64.7\,^\circ C$};\node at (O1) [below=8mm] {\tiny $\rm dp=1.700\,D$};\end{tikzpicture}$

$\tdplotsetmaincoords{0}{0}\begin{tikzpicture}[scale=1,tdplot_main_coords,declare function = {opc=0.9;a=4.647; b=4.929; c=89.040; alpha=90; beta=90; gamma=90;vdw=2; lw=3;dp=1.700; bp=64.7;}]\coordinate (O1) at (1.047, 1.491, 8.411);\coordinate (C2) at (1.178, 2.723, 7.729); \coordinate (H1) at (1.744, 1.342, 8.855); \coordinate (H2A) at (1.280, 3.448, 8.380); \coordinate (H2B) at (0.378, 2.883, 7.185); \coordinate (H2C) at (1.967, 2.693, 7.147); \coordinate (CO1) at (-1.276, 0.973, 9.670); \coordinate (CC2) at (-1.145, -0.259, 10.352); \coordinate (CH1) at (-0.579, 1.123, 9.226); \coordinate (CH2A) at (-1.044, -0.984, 9.700); \coordinate (CH2B) at (-1.946, -0.418, 10.895); \coordinate (CH2C) at (-0.357, -0.229, 10.933); \coordinate (AO1) at (3.371, 0.973, 9.670); \coordinate (AC2) at (3.501, -0.259, 10.352); \coordinate (AH1) at (4.068, 1.123, 9.226); \coordinate (AH2A) at (3.603, -0.984, 9.700); \coordinate (AH2B) at (2.701, -0.418, 10.895); \coordinate (AH2C) at (4.290, -0.229, 10.933);\draw[line width = lw, gray] (O1) -- (C2);\draw[line width = lw, Pink1] (H1) -- (O1);\draw[line width = lw, Pink1] (C2) -- (H2A);\draw[line width = lw, Pink1] (H2B) -- (C2);\draw[line width = lw, Pink1] (C2) -- (H2C);\draw[line width = lw, gray] (CO1) -- (CC2);\draw[line width = lw, Pink1] (CH1) -- (CO1);\draw[line width = lw, Pink1] (CC2) -- (CH2A);\draw[line width = lw, Pink1] (CH2B) -- (CC2);\draw[line width = lw, Pink1] (CC2) -- (CH2C);\draw[line width = lw, gray] (AO1) -- (AC2);\draw[line width = lw, Pink1] (AH1) -- (AO1);\draw[line width = lw, Pink1] (AC2) -- (AH2A);\draw[line width = lw, Pink1] (AH2B) -- (AC2);\draw[line width = lw, Pink1] (AC2) -- (AH2C);\draw[line width = lw, blue, densely dotted] (H1) -- (AO1);\draw[line width = lw, blue, densely dotted] (CH1) -- (O1);\shade[ball color = black, opacity=opc] (C2) circle (vdw*1.70 mm);\shade[ball color = red, opacity=opc] (O1) circle (vdw*1.52 mm);\shade[ball color = white, opacity=opc] (H1) circle (vdw*1.20 mm);\shade[ball color = white, opacity=opc] (H2A) circle (vdw*1.20 mm);\shade[ball color = white, opacity=opc] (H2B) circle (vdw*1.20 mm);\shade[ball color = white, opacity=opc] (H2C) circle (vdw*1.20 mm);\shade[ball color = black, opacity=opc] (CC2) circle (vdw*1.70 mm);\shade[ball color = red, opacity=opc] (CO1) circle (vdw*1.52 mm);\shade[ball color = white, opacity=opc] (CH1) circle (vdw*1.20 mm);\shade[ball color = white, opacity=opc] (CH2A) circle (vdw*1.20 mm);\shade[ball color = white, opacity=opc] (CH2B) circle (vdw*1.20 mm);\shade[ball color = white, opacity=opc] (CH2C) circle (vdw*1.20 mm);\shade[ball color = black, opacity=opc] (AC2) circle (vdw*1.70 mm);\shade[ball color = red, opacity=opc] (AO1) circle (vdw*1.52 mm);\shade[ball color = white, opacity=opc] (AH1) circle (vdw*1.20 mm);\shade[ball color = white, opacity=opc] (AH2A) circle (vdw*1.20 mm);\shade[ball color = white, opacity=opc] (AH2B) circle (vdw*1.20 mm);\shade[ball color = white, opacity=opc] (AH2C) circle (vdw*1.20 mm);\node at (O1) [below=5mm] {\tiny $\rm bp=64.7\,^\circ C$};\node at (O1) [below=8mm] {\tiny $\rm dp=1.700\,D$};\end{tikzpicture}$
　メタノールの水素結合
ヒドロキシ基が水素原子供与体でもあり、水素原子受容体でもある。