第111回薬剤師国家試験

$\begin{tikzpicture}[>=Stealth,font=\small,line width=0.6pt]\begin{scope}[xshift=0cm]\node[above left, xshift=2mm] at (0, 1.3) {放出制御膜};\draw[-latex] (-0.8, 1.3) .. controls (-0.7, 1) and (-0.4, 1.2) .. (-0.3, 0.8);\draw[] (0, 0) circle (1.1cm);\draw (0, 0) circle (0.85cm);\node[align=center] at (0, 0) {薬物層\\\scriptsize（固体薬物）};\node[draw, single arrow, minimum height=1.2cm, fill=gray!50,inner sep=2pt, anchor=west] at (1.2, 0.6) {\tiny　　　　　　　　　};\node at (1.7, 1) {①水の浸入};\end{scope}\begin{scope}[xshift=4.5cm]\draw[] (0, 0) circle (1.1cm);\draw (0, 0) circle (0.8cm);\node at (-0.1, 0.15) {\fontsize{7pt}{7pt} ②薬物の溶解};\foreach \a in {0, 45, 90, 135, 180, 225, 270, 315} {\draw[-latex] (\a:0.4) -- (\a:1.5);}\node[below, yshift=-1.5cm] at (0, 0) {③溶解した薬物の放出};\draw[thick, dash pattern=on 1.5pt off 1.5pt] (45:0.93) circle (0.37cm);\end{scope}\begin{scope}[xshift=9cm, yshift=-1.5cm]\draw[very thick, dash pattern=on 1.5pt off 1.5pt] (-1, 2.5) -- (-1, 4.5) -- (5.5, 4.5) -- (5.5, -0.5) -- (-1, -0.5) -- (-1, 1.6) -- (-3.45, 2.2) -- (-1, 2.5);\draw[-latex] (0, 0) -- (5.2, 0);\draw[-latex] (0, 0) -- (0, 4) node[rotate=90, pos=0.5, above] {薬物濃度};\draw[thin, densely dashed] (1.5, 0) -- (1.5, 4);\draw[thin, densely dashed] (3.5, 0) -- (3.5, 4);\draw[very thick] (0, 3) node[above right] {$C_{\rm in}$} -- (1.5, 3);\draw[very thick] (1.5, 3.3) -- (3.5, 0.5);\draw[very thick] (1.5, 3) -- (1.5, 3.3);\draw[very thick] (3.5, 0.5) -- (3.5, 0.3);\draw[very thick] (3.5, 0.3) -- (5, 0.3) node[above left] {$C_{\rm out}$};\draw[< - >, >=Straight Barb] (1.5, 1) -- (3.5, 1) node[midway, below] {$h$};\node[above] at (0.75, 3.8) {薬物層};\node[above] at (2.5, 3.8) {放出制御膜};\node[above] at (4.5, 3.8) {放出液};\end{scope}\end{tikzpicture}$

\begin{tikzpicture}[
>=Stealth,
font=\small,
line width=0.6pt
]
\begin{scope}[xshift=0cm]
\node[above left, xshift=2mm] at (0, 1.3) {放出制御膜};
\draw[-latex] (-0.8, 1.3) .. controls (-0.7, 1) and (-0.4, 1.2) .. (-0.3, 0.8);
\draw[] (0, 0) circle (1.1cm);
\draw (0, 0) circle (0.85cm);
\node[align=center] at (0, 0) {薬物層\\（固体薬物）};
\node[draw, single arrow, minimum height=1.2cm, fill=gray!50,
inner sep=2pt, anchor=west] at (1.2, 0.6) {\tiny　　　　　　　　　};
\node at (1.5, 1) {①水の浸入};
\end{scope}
\begin{scope}[xshift=4.5cm]
\draw[] (0, 0) circle (1.1cm);
\draw (0, 0) circle (0.8cm);
\node at (0, 0.15) {\scriptsize ②薬物の溶解};
\foreach \a in {0, 45, 90, 135, 180, 225, 270, 315} {
\draw[-latex] (\a:0.4) -- (\a:1.5);
}
\node[below, yshift=-1.5cm] at (0, 0) {③溶解した薬物の放出};
\draw[thick, dash pattern=on 1.5pt off 1.5pt] (45:0.93) circle (0.37cm);
\end{scope}
\begin{scope}[xshift=9cm, yshift=-1.5cm]
\draw[very thick, dash pattern=on 1.5pt off 1.5pt] (-1, 2.5) -- (-1, 4.5) -- (5.5, 4.5) -- (5.5, -0.5) -- (-1, -0.5) -- (-1, 1.6) -- (-3.45, 2.2) -- (-1, 2.5);
\draw[-latex] (0, 0) -- (5.2, 0);
\draw[-latex] (0, 0) -- (0, 4) node[rotate=90, pos=0.5, above] {薬物濃度};
\draw[thin, densely dashed] (1.5, 0) -- (1.5, 4);
\draw[thin, densely dashed] (3.5, 0) -- (3.5, 4);
\draw[very thick] (0, 3) node[above right] {$C_{\rm in}$} -- (1.5, 3);
\draw[very thick] (1.5, 3.3) -- (3.5, 0.5);
\draw[very thick] (1.5, 3) -- (1.5, 3.3);
\draw[very thick] (3.5, 0.5) -- (3.5, 0.3);
\draw[very thick] (3.5, 0.3) -- (5, 0.3) node[above left] {$C_{\rm out}$};
\draw[< - >, >=Straight Barb] (1.5, 1) -- (3.5, 1) node[midway, below] {$h$};
\node[above] at (0.75, 4) {薬物層};
\node[above] at (2.5, 4) {放出制御膜};
\node[above] at (4.5, 4) {放出液};
\end{scope}
\end{tikzpicture}