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![\sixheterov[ace]{3s==\sixheterov[]{2s==\PutBondLine(-5,4)(-5,-95){0.8pt};2s==\WedgeAsSubstX(180,-240)(95,-115);3s==\put(1,10){\HashWedgeAsSubstX(0,0)(0,-150)}\put(-37,-220){H};2s==\PutBondLine(-3,-150)(-3,-200){0.8pt};4s==\sixheterov[c]{5s==\HashWedgeAsSubstX(0,0)(-108,-77)\put(-270,-140){HO};6s==\HashWedgeAsSubstX(0,0)(-135,165)\put(-200,170){O}}{1GB==;2==(yl)}[a];5s==\PutBondLine(125,78)(460,78){4pt}}{1==(yl);3==\put(-250,-250){\tetrahedral{0==N;4==CH$\bf_3$}};4GB==H}[bf];5s==\PutBondLine(0,0)(-135,-160){0.8pt}}{6==HO}[]\hspace{2cm}\raisebox{-1.5cm}{\sixheteroh[ace]{5s==\PutBondLine(0,0)(160,-80){0.85pt};3s==\sixheteroh[]{5s==\WedgeAsSubst(0,0)(1,0){200};3s==\PutBondLine(130,170)(202,170){0.8pt};4s==\sixheteroh[]{2s==\textcolor{white}{\PutBondLine(97,-50)(97,50){2pt}};2s==\PutBondLine(97,-168)(97,342){0.8pt};}{2==(yl);2FB==HO;5D==O;6Su==H;6Sd==\lmoiety{O\,}}[a];3s==\put(-300,120){\sixheterov[b]{2==CH$\bf_2$}{4==}[adef]}}{1==(yl);3FA==H;3B==N}[f]}{6==\lmoiety{HO}}[]}](https://gaia-sb.iwate-med.ac.jp/pharm/filter/tex/pix.php/2bf3d7992fbcefe284148ddb056d5ce4.svg "\sixheterov[ace]{3s==\sixheterov[]{2s==\PutBondLine(-5,4)(-5,-95){0.8pt};2s==\WedgeAsSubstX(180,-240)(95,-115);3s==\put(1,10){\HashWedgeAsSubstX(0,0)(0,-150)}\put(-37,-220){H};2s==\PutBondLine(-3,-150)(-3,-200){0.8pt};4s==\sixheterov[c]{5s==\HashWedgeAsSubstX(0,0)(-108,-77)\put(-270,-140){HO};6s==\HashWedgeAsSubstX(0,0)(-135,165)\put(-200,170){O}}{1GB==;2==(yl)}[a];5s==\PutBondLine(125,78)(460,78){4pt}}{1==(yl);3==\put(-250,-250){\tetrahedral{0==N;4==CH$\bf_3$}};4GB==H}[bf];5s==\PutBondLine(0,0)(-135,-160){0.8pt}}{6==HO}[]\hspace{2cm}\raisebox{-1.5cm}{\sixheteroh[ace]{5s==\PutBondLine(0,0)(160,-80){0.85pt};3s==\sixheteroh[]{5s==\WedgeAsSubst(0,0)(1,0){200};3s==\PutBondLine(130,170)(202,170){0.8pt};4s==\sixheteroh[]{2s==\textcolor{white}{\PutBondLine(97,-50)(97,50){2pt}};2s==\PutBondLine(97,-168)(97,342){0.8pt};}{2==(yl);2FB==HO;5D==O;6Su==H;6Sd==\lmoiety{O\,}}[a];3s==\put(-300,120){\sixheterov[b]{2==CH$\bf_2$}{4==}[adef]}}{1==(yl);3FA==H;3B==N}[f]}{6==\lmoiety{HO}}[]}")
![\tdplotsetmaincoords{210}{20}\begin{tikzpicture}[scale=1,tdplot_main_coords,rotate=143,declare function = {opc=0.9;_cell.entry_id = DL-penicillamine_1559932;_cell.length_a = 10.218;_cell.length_b = 20.792;_cell.length_c = 24.616;_cell.angle_alpha = 90.00;_cell.angle_beta = 90.00;_cell.angle_gamma = 90.00;_symmetry.space_group_name_H-M = 'P 21 21 21';Cvdw=1.70 cm; Nvdw=1.55 cm; Ovdw=1.52 cm; Hvdw=1.20 cm; Bvdw=1.92 cm; Clvdw=1.75 cm; Fvdw=1.47 cm; Svdw=1.80 cm; Brvdw=1.85 cm; Ivdw=1.98 cm; Ptvdw=1.75 cm;vdw=1/5; lw=3;x0=6.335889; y0=8.129056; z0=12.410667;}]\coordinate (C1) at (6.421-x0, 8.716-y0,12.202-z0);\coordinate (N1) at (4.895-x0, 6.761-y0,11.922-z0);\coordinate (O1) at (7.101-x0, 5.780-y0,10.937-z0);\coordinate (S1) at (6.503-x0, 8.854-y0,10.336-z0);\coordinate (C2) at (6.155-x0, 7.260-y0,12.562-z0);\coordinate (O2) at (8.286-x0, 6.113-y0,12.773-z0);\coordinate (C3) at (7.291-x0, 6.308-y0,12.042-z0);\coordinate (C4) at (5.296-x0, 9.624-y0,12.768-z0);\coordinate (C5) at (7.775-x0, 9.177-y0,12.741-z0);\coordinate (H2) at (6.080-x0, 7.175-y0,13.556-z0);\coordinate (H1A) at (4.206-x0, 7.337-y0,12.067-z0);\coordinate (H1B) at (4.669-x0, 5.942-y0,12.247-z0);\coordinate (H4A) at (5.478-x0,10.558-y0,12.532-z0);\coordinate (H4B) at (4.434-x0, 9.354-y0,12.389-z0);\coordinate (H4C) at (5.264-x0, 9.537-y0,13.746-z0);\coordinate (H5A) at (7.921-x0,10.115-y0,12.498-z0);\coordinate (H5B) at (7.785-x0, 9.088-y0,13.719-z0);\coordinate (H5C) at (8.486-x0, 8.624-y0,12.355-z0);\foreach \labelx /\labely in {N1/H1A, N1/H1B, C2/H2, C4/H4A, C4/H4B, C4/H4C, C5/H5A, C5/H5B, C5/H5C} \draw[line width = lw, Pink1] (\labelx) -- (\labely);\draw[line width = lw, gray] (C4) -- (C1) -- (C2) -- (C3);\draw[line width = lw, gray] (C1) -- (C5);\draw[line width = lw, gray] (C2) -- (N1);\draw[line width = lw, green] (O1) -- (C3) -- (O2);\draw[line width = lw, Gold1] (C1) -- (S1);\foreach \label in {H1A, H1B, H2, H4A, H4B, H4C, H5A, H5B, H5C} \shade[ball color = white, opacity=opc] (\label) circle (vdw*Hvdw);\foreach \label in {C1, C2, C3, C4, C5} \shade[ball color = black, opacity=opc] (\label) circle (vdw*Cvdw);\foreach \label in {N1} \shade[ball color = blue, opacity=opc] (\label) circle (vdw*Nvdw);\foreach \label in {O1, O2} \shade[ball color = red, opacity=opc] (\label) circle (vdw*Ovdw);\foreach \label in {S1} \shade[ball color = Gold1, opacity=opc] (\label) circle (vdw*Svdw);\end{tikzpicture}](https://gaia-sb.iwate-med.ac.jp/pharm/filter/tex/pix.php/38405497eb71219e21c72c9de2707bf9.svg "\tdplotsetmaincoords{210}{20}\begin{tikzpicture}[scale=1,tdplot_main_coords,rotate=143,declare function = {opc=0.9;_cell.entry_id = DL-penicillamine_1559932;_cell.length_a = 10.218;_cell.length_b = 20.792;_cell.length_c = 24.616;_cell.angle_alpha = 90.00;_cell.angle_beta = 90.00;_cell.angle_gamma = 90.00;_symmetry.space_group_name_H-M = 'P 21 21 21';Cvdw=1.70 cm; Nvdw=1.55 cm; Ovdw=1.52 cm; Hvdw=1.20 cm; Bvdw=1.92 cm; Clvdw=1.75 cm; Fvdw=1.47 cm; Svdw=1.80 cm; Brvdw=1.85 cm; Ivdw=1.98 cm; Ptvdw=1.75 cm;vdw=1/5; lw=3;x0=6.335889; y0=8.129056; z0=12.410667;}]\coordinate (C1) at (6.421-x0, 8.716-y0,12.202-z0);\coordinate (N1) at (4.895-x0, 6.761-y0,11.922-z0);\coordinate (O1) at (7.101-x0, 5.780-y0,10.937-z0);\coordinate (S1) at (6.503-x0, 8.854-y0,10.336-z0);\coordinate (C2) at (6.155-x0, 7.260-y0,12.562-z0);\coordinate (O2) at (8.286-x0, 6.113-y0,12.773-z0);\coordinate (C3) at (7.291-x0, 6.308-y0,12.042-z0);\coordinate (C4) at (5.296-x0, 9.624-y0,12.768-z0);\coordinate (C5) at (7.775-x0, 9.177-y0,12.741-z0);\coordinate (H2) at (6.080-x0, 7.175-y0,13.556-z0);\coordinate (H1A) at (4.206-x0, 7.337-y0,12.067-z0);\coordinate (H1B) at (4.669-x0, 5.942-y0,12.247-z0);\coordinate (H4A) at (5.478-x0,10.558-y0,12.532-z0);\coordinate (H4B) at (4.434-x0, 9.354-y0,12.389-z0);\coordinate (H4C) at (5.264-x0, 9.537-y0,13.746-z0);\coordinate (H5A) at (7.921-x0,10.115-y0,12.498-z0);\coordinate (H5B) at (7.785-x0, 9.088-y0,13.719-z0);\coordinate (H5C) at (8.486-x0, 8.624-y0,12.355-z0);\foreach \labelx /\labely in {N1/H1A, N1/H1B, C2/H2, C4/H4A, C4/H4B, C4/H4C, C5/H5A, C5/H5B, C5/H5C} \draw[line width = lw, Pink1] (\labelx) -- (\labely);\draw[line width = lw, gray] (C4) -- (C1) -- (C2) -- (C3);\draw[line width = lw, gray] (C1) -- (C5);\draw[line width = lw, gray] (C2) -- (N1);\draw[line width = lw, green] (O1) -- (C3) -- (O2);\draw[line width = lw, Gold1] (C1) -- (S1);\foreach \label in {H1A, H1B, H2, H4A, H4B, H4C, H5A, H5B, H5C} \shade[ball color = white, opacity=opc] (\label) circle (vdw*Hvdw);\foreach \label in {C1, C2, C3, C4, C5} \shade[ball color = black, opacity=opc] (\label) circle (vdw*Cvdw);\foreach \label in {N1} \shade[ball color = blue, opacity=opc] (\label) circle (vdw*Nvdw);\foreach \label in {O1, O2} \shade[ball color = red, opacity=opc] (\label) circle (vdw*Ovdw);\foreach \label in {S1} \shade[ball color = Gold1, opacity=opc] (\label) circle (vdw*Svdw);\end{tikzpicture}")
![\tdplotsetmaincoords{-55}{24}\begin{tikzpicture}[scale=1,tdplot_main_coords,rotate=-43,declare function = {opc=0.9;_cell.entry_id = DL-penicillamine_1559932;_cell.length_a = 10.218;_cell.length_b = 20.792;_cell.length_c = 24.616;_cell.angle_alpha = 90.00;_cell.angle_beta = 90.00;_cell.angle_gamma = 90.00;_symmetry.space_group_name_H-M = 'P 21 21 21';Cvdw=1.70 cm; Nvdw=1.55 cm; Ovdw=1.52 cm; Hvdw=1.20 cm; Bvdw=1.92 cm; Clvdw=1.75 cm; Fvdw=1.47 cm; Svdw=1.80 cm; Brvdw=1.85 cm; Ivdw=1.98 cm; Ptvdw=1.75 cm;vdw=1/5; lw=3;x0=3.527778; y0=5.344667; z0=7.798889;}]\coordinate (N2) at (4.678-x0, 4.701-y0, 9.354-z0);\coordinate (S2) at (3.207-x0, 7.327-y0, 8.760-z0);\coordinate (O3) at (6.242-x0, 6.354-y0, 7.976-z0);\coordinate (O4) at (5.771-x0, 5.341-y0, 6.061-z0);\coordinate (C6) at (3.032-x0, 5.751-y0, 7.796-z0);\coordinate (C7) at (4.310-x0, 4.923-y0, 7.949-z0);\coordinate (C8) at (5.547-x0, 5.610-y0, 7.257-z0);\coordinate (C9) at (2.689-x0, 6.038-y0, 6.329-z0);\coordinate (C10) at (1.865-x0, 4.953-y0, 8.414-z0);\coordinate (H7) at (4.162-x0, 4.034-y0, 7.515-z0);\coordinate (H2A) at (5.334-x0, 4.075-y0, 9.435-z0);\coordinate (H2B) at (3.959-x0, 4.454-y0, 9.854-z0);\coordinate (H9A) at (1.867-x0, 6.568-y0, 6.282-z0);\coordinate (H9B) at (3.423-x0, 6.535-y0, 5.913-z0);\coordinate (H9C) at (2.559-x0, 5.190-y0, 5.854-z0);\coordinate (H10A) at (1.035-x0, 5.466-y0, 8.325-z0);\coordinate (H10B) at (1.771-x0, 4.098-y0, 7.944-z0);\coordinate (H10C) at (2.049-x0, 4.786-y0, 9.362-z0);\foreach \labelx /\labely in {N2/H2A, N2/H2B, C7/H7, C9/H9A, C9/H9B, C9/H9C, C10/H10A, C10/H10B, C10/H10C} \draw[line width = lw, Pink1] (\labelx) -- (\labely);\draw[line width = lw, gray] (C9) -- (C6) -- (C7) -- (C8);\draw[line width = lw, gray] (C6) -- (C10);\draw[line width = lw, gray] (C7) -- (N2);\draw[line width = lw, green] (O3) -- (C8) -- (O4);\draw[line width = lw, Gold1] (C6) -- (S2);\foreach \label in {H2A, H2B, H7, H9A, H9B, H9C, H10A, H10B, H10C} \shade[ball color = white, opacity=opc] (\label) circle (vdw*Hvdw);\foreach \label in {C6, C7, C8, C9, C10} \shade[ball color = black, opacity=opc] (\label) circle (vdw*Cvdw);\foreach \label in {N2} \shade[ball color = blue, opacity=opc] (\label) circle (vdw*Nvdw);\foreach \label in {O3, O4} \shade[ball color = red, opacity=opc] (\label) circle (vdw*Ovdw);\foreach \label in {S2} \shade[ball color = Gold1, opacity=opc] (\label) circle (vdw*Svdw);\end{tikzpicture}](https://gaia-sb.iwate-med.ac.jp/pharm/filter/tex/pix.php/08aaf49f85b79c24ed671a8139dff4ee.svg "\tdplotsetmaincoords{-55}{24}\begin{tikzpicture}[scale=1,tdplot_main_coords,rotate=-43,declare function = {opc=0.9;_cell.entry_id = DL-penicillamine_1559932;_cell.length_a = 10.218;_cell.length_b = 20.792;_cell.length_c = 24.616;_cell.angle_alpha = 90.00;_cell.angle_beta = 90.00;_cell.angle_gamma = 90.00;_symmetry.space_group_name_H-M = 'P 21 21 21';Cvdw=1.70 cm; Nvdw=1.55 cm; Ovdw=1.52 cm; Hvdw=1.20 cm; Bvdw=1.92 cm; Clvdw=1.75 cm; Fvdw=1.47 cm; Svdw=1.80 cm; Brvdw=1.85 cm; Ivdw=1.98 cm; Ptvdw=1.75 cm;vdw=1/5; lw=3;x0=3.527778; y0=5.344667; z0=7.798889;}]\coordinate (N2) at (4.678-x0, 4.701-y0, 9.354-z0);\coordinate (S2) at (3.207-x0, 7.327-y0, 8.760-z0);\coordinate (O3) at (6.242-x0, 6.354-y0, 7.976-z0);\coordinate (O4) at (5.771-x0, 5.341-y0, 6.061-z0);\coordinate (C6) at (3.032-x0, 5.751-y0, 7.796-z0);\coordinate (C7) at (4.310-x0, 4.923-y0, 7.949-z0);\coordinate (C8) at (5.547-x0, 5.610-y0, 7.257-z0);\coordinate (C9) at (2.689-x0, 6.038-y0, 6.329-z0);\coordinate (C10) at (1.865-x0, 4.953-y0, 8.414-z0);\coordinate (H7) at (4.162-x0, 4.034-y0, 7.515-z0);\coordinate (H2A) at (5.334-x0, 4.075-y0, 9.435-z0);\coordinate (H2B) at (3.959-x0, 4.454-y0, 9.854-z0);\coordinate (H9A) at (1.867-x0, 6.568-y0, 6.282-z0);\coordinate (H9B) at (3.423-x0, 6.535-y0, 5.913-z0);\coordinate (H9C) at (2.559-x0, 5.190-y0, 5.854-z0);\coordinate (H10A) at (1.035-x0, 5.466-y0, 8.325-z0);\coordinate (H10B) at (1.771-x0, 4.098-y0, 7.944-z0);\coordinate (H10C) at (2.049-x0, 4.786-y0, 9.362-z0);\foreach \labelx /\labely in {N2/H2A, N2/H2B, C7/H7, C9/H9A, C9/H9B, C9/H9C, C10/H10A, C10/H10B, C10/H10C} \draw[line width = lw, Pink1] (\labelx) -- (\labely);\draw[line width = lw, gray] (C9) -- (C6) -- (C7) -- (C8);\draw[line width = lw, gray] (C6) -- (C10);\draw[line width = lw, gray] (C7) -- (N2);\draw[line width = lw, green] (O3) -- (C8) -- (O4);\draw[line width = lw, Gold1] (C6) -- (S2);\foreach \label in {H2A, H2B, H7, H9A, H9B, H9C, H10A, H10B, H10C} \shade[ball color = white, opacity=opc] (\label) circle (vdw*Hvdw);\foreach \label in {C6, C7, C8, C9, C10} \shade[ball color = black, opacity=opc] (\label) circle (vdw*Cvdw);\foreach \label in {N2} \shade[ball color = blue, opacity=opc] (\label) circle (vdw*Nvdw);\foreach \label in {O3, O4} \shade[ball color = red, opacity=opc] (\label) circle (vdw*Ovdw);\foreach \label in {S2} \shade[ball color = Gold1, opacity=opc] (\label) circle (vdw*Svdw);\end{tikzpicture}")
強塩基性条件下の (2R)-2-amino-3-methyl-3-sulfanylbutanoic acid（L-ペニシラミン）![\SevenCycle(0,0){141}[]{2==;6==}[acdfg]\PutBondLine(-353,83)(-353,-280){0.8pt}\xFiveCycle(328,-155){12}[b]{1s==\PutDashedBond(0,0)(-150,-50){0.8pt};2=={\sffamily\bfseries N};4s==\WedgeAsSubstX(0,0)(80,130)[10]\PutDashedBond(0,0)(-80,130){0.8pt}\put(-80,130){\exosinglebond{78}};5s==\PutDashedBond(0,0)(-90,120){0.8pt}\WedgeAsSubstX(0,0)(-130,-80)[10]}[a]\put(-300,580){\sffamily\bfseries H}\put(-770,360){\sffamily\bfseries H$\bf_3$C}\put(-720,-30){\sffamily\bfseries H$\bf_3$C}\xFiveCycle(531,427){23}[e]{3=={\sffamily\bfseries N};1s==\WedgeAsSubstX(0,0)(0,-150)[10]\PutDashedBond(0,0)(-150,-80){0.8pt};4s==\WedgeAsSubstX(0,0)(-80,130)[10];5s==\WedgeAsSubstX(0,0)(-80,130)[10]\PutDashedBond(0,0)(-130,-80){0.8pt}}[c]\put(-310,-830){\sffamily\bfseries CH$\bf_3$}\put(-575,-195){\sffamily\bfseries H}\put(-630,-640){\sffamily\bfseries 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