オセルタミビルのSBDD

オセルタミビルのSBDD

by 孝昌 野中 -
Number of replies: 0

\decaheterovb[]{8==\hspace{-0.3mm}{O};9==\put(-120,5){O};9s==\put(-40,50){\tikz\draw[line width=0.8pt,densely dotted](0,0) -- (0.5,0.3) -- (0.5,0.8);};1s==\sixheterov[e]{1==O;3s==\decaheterov[]{5==\downnobond{N}{H};9s==\put(-35,50){\exodoublebond{0}};{{10}}==O}{6==(yl)}[abcfghijk];2s==\decaheterovt[]{3==OH;9s==\put(35,30){\adddash(0,0)(-2,1){130}};{{10}}==HO}{5FB==OH;6==(yl)}[abghijk];2s==\WedgeAsSubstX(0,0)(180,110)[10]}{3A==;4B==OH;6==(yl)}[]}{}[abcdefgh]\put(-650,700){\text{⊖}}  \decaheterovb[]{8==\hspace{-0.3mm}{O};9==\put(-120,5){O};9s==\put(-40,50){\tikz\draw[line width=0.8pt,densely dotted](0,0) -- (0.5,0.3) -- (0.5,0.8);};1s==\sixheterov[e]{1==O;3s==\decaheterov[]{5==\downnobond{N}{H};9s==\put(-35,50){\exodoublebond{0}};{{10}}==O}{6==(yl)}[abcfghijk];2s==\decaheterovt[]{3==OH;9s==\put(35,30){\adddash(0,0)(-2,1){130}};{{10}}==HO}{5FB==OH;6==(yl)}[abghijk];2s==\WedgeAsSubstX(0,0)(180,110)[10]}{3A==;4B==NH$\bf_3$;6==(yl)}[]}{}[abcdefgh]\put(-650,700){\text{⊖}}\put(-220,-50){\text{⊕}}  \spc\\\decaheterovb[]{8==\hspace{-0.3mm}{O};9==\put(-120,5){O};9s==\put(-40,50){\tikz\draw[line width=0.8pt,densely dotted](0,0) -- (0.5,0.3) -- (0.5,0.8);};1s==\sixheterov[f]{3s==\decaheterov[]{5==\downnobond{N}{H};9s==\put(-35,50){\exodoublebond{0}};{{10}}==O}{6==(yl)}[abcfghijk];2s==\decaheterovt[]{5==O}{6==(yl)}[abfghi];2s==\WedgeAsSubstX(0,0)(130,80)[10]}{3A==;4B==NH$\bf_3$;6==(yl)}[]}{}[abcdefgh]\put(-650,700){\text{⊖}}\put(-220,-50){\text{⊕}}  
    DANA         4-Amino-DANA       Oseltamivir Acid

 

DANA: (2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid

             2-Deoxy-2,3-dehydro-N-AcetylNeuraminic Acid(Neu5Ac2en)

 

4-Amino-DANA: (2R,3R,4S)-3-acetamido-4-amino-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid

                             4-Amino-2-Deoxy-2,3-didehydro-N-AcetylNeuraminic Acid(4-Amino-neu5Ac2en)

        アミノ基をグアニジノ基に置換したものを Zanamivir という。

 

Oseltamivir Acid: (3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylic acid

 


\decaheterovb[]{8==\hspace{-0.3mm}{O};9==\put(-120,5){O};
9s==\put(-40,50){\tikz\draw[line width=0.8pt,densely dotted](0,0) -- (0.5,0.3) -- (0.5,0.8);};
1s==\sixheterov[e]{1==O;
3s==\decaheterov[]{5==\downnobond{N}{H};9s==\put(-35,50){\exodoublebond{0}};{{10}}==O}{6==(yl)}[abcfghijk];
2s==\decaheterovt[]{3==OH;9s==\put(35,30){\adddash(0,0)(-2,1){130}};{{10}}==HO}{5FB==OH;6==(yl)}[abghijk];
2s==\WedgeAsSubstX(0,0)(180,110)[10]
}{3A==;4B==OH;6==(yl)}[]
}{}[abcdefgh]
\put(-650,700){\text{⊖}}

 


\decaheterovb[]{8==\hspace{-0.3mm}{O};9==\put(-120,5){O};
9s==\put(-40,50){\tikz\draw[line width=0.8pt,densely dotted](0,0) -- (0.5,0.3) -- (0.5,0.8);};
1s==\sixheterov[e]{1==O;
3s==\decaheterov[]{5==\downnobond{N}{H};9s==\put(-35,50){\exodoublebond{0}};{{10}}==O}{6==(yl)}[abcfghijk];
2s==\decaheterovt[]{3==OH;9s==\put(35,30){\adddash(0,0)(-2,1){130}};{{10}}==HO}{5FB==OH;6==(yl)}[abghijk];
2s==\WedgeAsSubstX(0,0)(180,110)[10]
}{3A==;4B==NH$\bf_3$;6==(yl)}[]
}{}[abcdefgh]
\put(-650,700){\text{⊖}}
\put(-220,-50){\text{⊕}}

 


\decaheterovb[]{8==\hspace{-0.3mm}{O};9==\put(-120,5){O};
9s==\put(-40,50){\tikz\draw[line width=0.8pt,densely dotted](0,0) -- (0.5,0.3) -- (0.5,0.8);};
1s==\sixheterov[f]{
3s==\decaheterov[]{5==\downnobond{N}{H};9s==\put(-35,50){\exodoublebond{0}};{{10}}==O}{6==(yl)}[abcfghijk];
2s==\decaheterovt[]{5==O}{6==(yl)}[abfghi];
2s==\WedgeAsSubstX(0,0)(130,80)[10]
}{3A==;4B==NH$\bf_3$;6==(yl)}[]
}{}[abcdefgh]
\put(-650,700){\text{⊖}}
\put(-220,-50){\text{⊕}}