Ishida N, Saito M, Sato S, Koepsell H, Taira E, Hirose M. SGLT1 participates in the development of vascular cognitive impairment in a mouse model of small vessel disease. Neurosci  Lett, in press.

Saito M, Ishida N, Yamada H, Ibi M, Hirose M. 8-HEPE-concentrated materials from Pacific krill improve plasma cholesterol levels and hepatic steatosis in high cholesterol diet-fed low-density lipoprotein (LDL) receptor-deficient mice. Biol Pharm Bull, in press.



Matsushita N, Ishida N, Ibi M, Saito M, Takahashi M, Morino Y, Taira E, Taniguchi S, Iwakura Y, Sawa Y, Hirose M. IL-1β Plays an Important Role in Pressure Overload-Induced Atrial Fibrillation in Mice. Biol Pharm Bull, 42(4): 543-546, 2019

Sawa, Y., Saito, M., Ishida, N., Ibi, M, Matsushita, N., Morino, Y., Taira, E., Hirose, M. Pretreatment with KGA-2727, a Selective SGLT1 Inhibitor, is Protective against Myocardial Infarction-Induced Ventricular Remodeling and Heart Failure in Mice. J Pharmacol Sci, 142(1): 16-25, 2020


Hirose, M. Current Topics ~ Inflammation and Tissue Remodeling as Potential Therapeutic Targets~ Foreword. Biol Pharm Bull, 42(4): 517, 2019

Ibi M. Inflammation and Temporomandibular Joint Derangement. Biol Pharm Bull, 42(4): 538-542, 2019



Matsushita N, Ishida N, Ibi M, Saito M, Sanbe A, Shimojo H, Suzuki S, Koepsell H, Takeishi Y, Morino Y, Taira E, Sawa Y, Hirose M. Chronic Pressure Overload Induces Cardiac Hypertrophy and Fibrosis via Increases in SGLT1 and IL-18 Gene Expression in Mice. Int Heart J, 59(5): 1123-1133, 2018


弘瀬 雅教, 松下 尚子, 石田 菜々絵, 衣斐 美歩, 斎藤 麻希. 心筋リモデリングと Na+/グルコース共輸送体タンパク1(SGLT1). Yakugaku Zasshi, 138(7): 939-943, 2018



Takizawa N*, Okubo N*, Kamo M, Chosa N, Mikami T, Suzuki K, Yokota S, Ibi M, Ohtsuka M., Taira M., Yaegashi T., Ishisaki A., Kyakumoto S. (*co-first authors) Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatory macrophages in cell-to-cell contact-independent and -dependent manners under hypoxic culture. Exp Cell Res, 358: 411-420, 2017.

Ueno M, Suzuki J, Hirose M, Sato S, Imagawa M, Zenimaru Y, Takahashi S, Ikuyama S, Koizumi T, Konoshita T, Kraemer FB, Ishizuka T. Cardiac overexpression of perilipin 2 induces dynamic steatosis: prevention by hormone-sensitive lipase. Am J Physiol Endocrinol Metab, 313: E699–E709, 2017.

Ibi M., Horie S., Kyakumoto S., Chosa N., Yoshida M., Kamo M., Ohtsuka M., Ishisaki A. Cell-cell interactions between monocytes/macrophages and synoviocyte-like cells promote inflammatory cell infiltration mediated by augmentation of MCP-1 production in temporomandibular joint. Biosci Rep, 38(2), pii: BSR20171217. doi: 10.1042/BSR20171217, 2018

Inomata Y, Nagasaka S, Miyate K, Goto Y, Hino C, Toukairin C, Higashio R, Ishida K, Saino T, Hirose M, Tsumura H, Sanbe A. Bcl-2-associated athanogene 3 (BAG3) is an enhancer of small heat shock protein turnover via activation of autophagy in the heart. Biochem Biophys Res Commun. 496(4):1141-1147, 2018



Yamada H, Kikuchi S, Hakozaki M, Motodate K, Nagahora N, Hirose M. 8-Hydroxyeicosapentaenoic Acid Decreases Plasma and Hepatic Triglycerides via Activation of Peroxisome Proliferator-Activated Receptor Alpha in High-Fat Diet-Induced Obese Mice. J Lipids, article ID7498508, 2016

Komatsu Y, Ibi M, Chosa N, Kyakumoto S, Kamo M, Shibata T, Sugiyama Y, Ishisaki A. Zoledronic acid suppresses transforming growth factor-β-induced fibrogenesis by human gingival fibroblasts. Int J Mol Med, 38(1):139-47, 2016



Hirose M, Matsushita N. Mechanical stretch and endothelial to mesenchymal transition – importance of integrin β. Circ J. 79(1):53-4, 2015

Gautam M, Fujita D, Kimura K, Ichikawa H, Izawa A, Hirose M, Kashihara T, Yamada M, Takahashi M, Ikeda U, Shiba Y. Transplantation of adipose tissue-derived stem cells improves cardiac contractile function and electrical stability in a rat myocardial infarction model. J Mol Cell Cardiol. 81:139-49, 2015

Mori A, Namekawa R, Hasebe M, Saito M, Sakamoto K, Nakahara T, Ishii K. Involvement of prostaglandin I2 in nitric oxide-induced vasodilation of retinal arterioles in rats. Eur J Pharmacol. 764:249-55, 2015

Tanabe Y, Saito MT, Nakayama K. Mechanical Stretching and Signaling Pathways in Adipogenesis. Stud Mechanobiol Tissue Eng Biomat. 16: 35-62, 2015



Hirose M, Shibazaki T, Nakada T, Kashihara T, Yano S, Okamoto Y, Isaji M, Matsushita N, Taira E, Yamada M.  Phlorizin prevents electrically-induced ventricular tachyarrhythmia during ischemia in Langendorff-perfused guinea-pig hearts. Biol Pharm Bull. 37 (7): 1168-76, 2014

Matsushita N, Hirose M, Sanbe A, Kondo Y, Irie Y, Taira E. Nicorandil improves electrical remodeling, leading to the prevention of electrically induced ventricular tachyarrhythmia in a mouse model of desmin-related cardiomyopathy. Clin Exp Pharm Physiol. 41: 89-97, 2014

Matsushita N, Kashihara T, Shimojo H, Suzuki S, Nakada T, Takeishi Y, Mende U, Taira E, Yamada M, Sanbe A, Hirose M. Cardiac overexpression of constitutively active Gαq causes angiotensin II type 1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice. PLoS One. 9 (8): e106354, 2014

Hirose M, Matsushita N. Mechanical stretch and endothelial to mesenchymal transition – importance of integrin β1. Circ J. 2015; 79 (1): 53-4, 2014



Yoshihara T, Yonoki Y, Saito M, Nakahara T, Sakamoto K, Ishii K. Agonist-induced receptor internalization in Chinese hamster ovary cells stably co-expressing β1– and β2-adrenergic receptors. Biol Pharm Bull. 36(1):114-9, 2013

Misaka T, Suzuki S, Miyata M, Kobayashi A, Shishido T, Ishigami A, Saitoh S, Hirose M, Kubota I, Takeishi Y. Deficiency of senescence marker protein 30 exacerbates angiotensin II-induced cardiac remodelling. Cardiovasc Res.99(3):461-70, 2013

Laurita KR, Hirose M. Electrical vagal stimulation and cardioprotection. Heart Rhythm. 10(11):1708-9, 2013

Matsushita N, Hirose M, Sanbe A, Kondo Y, Irie Y, Taira E. Nicorandil improves electrical remodeling, leading to the prevention of electrically induced ventricular tachyarrhythmia in a mouse model of desmin-related cardiomyopathy. Clin Exp Pharmacol Physiol. 41(1):89-97, 2014

Kashihara T, Hirose M, Shimojo H, Nakada T, Gomi S, Hongo M, Yamada M. β2-Adrenergic and M2-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure. Eur J Pharmacol. 724:122-31, 2014



Hirose M, Matsushita N. A new therapeutic approach for postoperative systemic inflammation: Effectiveness of epicardial ganglionated plexus stimulation. Heart Rhythm. 9:951-952, 2012

Kashihara T, Nakada T, Shimojo H, Horiuchi-Hirose M, Gomi S, Shibazaki T, Sheng X, Hirose M, Hongo M, Yamada M. Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca2+ channel activity through phosphatases in heart failure. Am J Physiol Heart Circ Physiol 302:H1645-H1654, 2012

Sheng X, Nakada T, Kobayashi M, Kashihara T, Shibazaki T, Horiuchi-Hirose M, Gomi S, Hirose M, Aoyama T, Yamada M. Two mechanistically distinct effects of dihydropyridine nifedipine on CaV1.2 L-type Ca2+ channels revealed by Timothy syndrome mutation. Eur J Pharmacol., 685:15-23, 2012

Nakada T, Flucher BE, Kashihara T, Sheng X, Shibazaki T, Horiuchi-Hirose M, Gomi S, Hirose M, Yamada M. Proximal C-terminus of a1C subunits is necessary for unctional membrane-targeting of cardiac L-type calcium channels. Biochemical J. 448,:221-231, 2012

Hirose M, Takeishi Y, Nakada T, Shimojo H, Kashihara T, Nishio A, Suzuki S, Mende U, Matsumoto K, Matsushita N, Taira E, Yamada M. Nicorandil prevents Gαq-induced progressive heart failure and ventricular arrhythmias in transgenic mice. PLoS One 7(12):e52667, 2012

Tanabe Y, Saito-Tanji M, Morikawa Y, Kamataki A, Sawai T, Nakayama K. Role of Secretory Phospholipase A2 in Rhythmic Contraction of Pulmonary Arteries of Rats with Monocrotaline-Induced Pulmonary Arterial Hypertension. J Pharmacol Sci. 119:271-281, 2012

松下 尚子、平 英一、弘瀬 雅教、阿南 如子、三部 篤. デスミン関連心筋症で誘発される不整脈に対するニコランジルの改善作用メカニズム. Ther Res 34:293-295, 2013



Hara Y, Wakino S, Tanabe Y, Saito M, Tokuyama H, Washida N, Tatematsu S, Yoshioka K, Homma K, Hasegawa K, Minakuchi H, Fujimura K, Hosoya K, Hayashi K, Nakayama K, Itoh H. Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch. Sci Signal., 4:ra3, 2011.

Tanabe Y, Saito M, Morikawa Y, Kamataki A, Sawai T, Hirose M, Nakayama. Inhibition of untransformed prostaglandin H2 production and stretch-induced contraction of rabbit pulmonary arteries by indoxam, a selective secretory phospholipase A2 inhibitor. J Pharmacol Sci., 115:525-31, 2011.

Sakamoto K, Ohki K, Saito M, Nakahara T, Ishii. Small molecule cyclin-dependent kinase inhibitors protect against neuronal cell death in the ischemic-reperfused rat retina. J Ocul Pharmacol Ther., 27: 419-25, 2011

Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, Kashihara T, Horiuchi-Hirose M, Kubota I, Mende U, Yamada M. Diacylglycerol kinase ζ inhibits ventricular tachyarrhythmias in a mouse model of heart failure: Roles of canonical transient receptor potential (TRPC) channels. Circ J., 75:2333-2342, 2011.

Horiuchi-Hirose M, Kashihara T, Nakada T, Kurebayashi N, Shimojo H, Shibazaki T, Sheng X, Yano S, Hirose M, Hongo M, Sakurai T, Moriizumi T, Ueda H, Yamada M. Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes. Am J Physiol Heart Circ Physiol. 300(3):H978-88, 2011

Tsujino N, Nakada T, Tsubouchi K, Kobayashi M, Kawai Y, Yano S, Matsunaga T, Hirose M, Ohmori S, Ohhashi T, Yamada M. Thrombin activates Ca2+-permeating nonselective cation channels through protein kinase C in human umbilical vein endothelial cells. Shinshu Med. J 59;13-26, 2011

Hirose M, Yano S, Nakada T, Horiuchi-Hirose M, Tsujino N, Yamada M. Nicorandil ameliorates impulse conduction disturbances during ischemia in isolated arterially perfused canine atria. Int J Cardiol 146:37-43, 2011

弘瀬雅教、三部篤、西郡秀夫、中山貢一 デスミン関連心筋症で誘発される不整脈に対するニコランジルの効果. Ther Res. 33: 480-481, 2012



Sakamoto K, Ohki K, Saito M, Nakahara T, Ishii K. Histological protection by donepezil against neurodegeneration induced by ischemia-reperfusion in the rat retina. J Pharmacol Sci. 112(3): 327-335, 2010

Sakamoto K, Hiraiwa M, Saito M, Nakahara T, Sato Y, Nagao T, Ishii K. Protective effect of all-trans retinoic acid on NMDA-induced neuronal cell death in rat retina. Eur J Pharmacol. 635(1-3): 56-61, 2010

Hirose M. A new specific risk marker for Post-MI fatal arrhythmias: Significance of attenuated recovery of baroreflex sensitivity. Heart Rhythm 7: 236-237, 2010

Yano S, Hirose M, Nakada T, Nakayama J, Matsuo K, Yamada M. Selective alpha 1A-adrenoceptor stimulation induces Mueller’s smooth muscle contraction in an isolated canine upper eyelid preparation. Eye. Res. 35: 363-369, 2010