Department of Immunobiology
School of Pharmacy, Iwate Medical University


Professor Ayako OHASHI-KOBAYASHI, Ph.D.
Specially-Appointed Professor Hirohisa SHIRAISHI, Ph.D.
Assistant professor Takahiro TANJI, Ph.D.
Assistant professor Kenji NISHIKORI, Ph.D.


A new microsporidium Percutemincola moriokae gen. nov., sp. nov. from Oscheius tipulae: A novel model of microsporidia–nematode associations.
Nishikori K, Setiamarga D H E, Tanji T, Kuroda E, Shiraishi H, Ohashi-Kobayashi A.
Parasitology. Published online: 17 April 2018.

Molecular dissection of Caenorhabditis elegans ATP-binding cassette transporter protein HAF-4 to investigate its subcellular localization and dimerization.
Tanji T, Shiraishi H, Nishikori K, Aoyama R, Ohashi K, Maeda M, Ohashi-Kobayashi A.
Biochem Biophys Res Commun. 2017 Aug 19;490(2):78-83.

Characterization of HAF-4- and HAF-9-localizing organelles as distinct organelles in Caenorhabditis elegans intestinal cells.
Tanji T, Nishikori K, Haga S, Kanno Y, Kobayashi Y, Takaya M, Gengyo-Ando K, Mitani S, Shiraishi H, Ohashi-Kobayashi A.
BMC Cell Biol. 2016 Jan 27;17(1):4.

Amino-terminal extension of 146 residues of L-type GATA-6 is required for transcriptional activation but not for self-association.
Takada K, Obayashi K, Ohashi K, Ohashi-Kobayashi A, Nakanishi-Matsui M, Maeda M.
Biochem Biophys Res Commun. 2014 Oct 3;452(4):962-6.

Intracellular localization of ABC transporter TAPL differs between transient and stable expression.
Motohashi Y, Ohashi-Kobayashi A, Nakanishi-Matsui M, Fujimoto Y, Maeda, M.
CellBio 2014;3(2):50-59.

Co-operative function and mutual stabilization of the half ATP-binding cassette transporters HAF-4 and HAF-9 in Caenorhabditis elegans.
Tanji T, Nishikori K, Shiraishi H, Maeda M, Ohashi-Kobayashi A.
Biochem J. 2013 Jun 15;452(3):467-75.

Role of the PEST sequence in the long-type GATA-6 DNA-binding protein expressed in human cancer cell lines.
Obayashi K, Takada K, Ohashi K, Kobayashi-Ohashi A, Maeda M.
Adv Biosci Biotechnol. 2012;3(4):314-20.

Transporter associated with antigen processing-like (ABCB9) stably expressed in Chinese hamster ovary-K1 cells is sorted to the microdomains of lysosomal membranes.
Fujimoto Y, Kamakura A, Motohashi Y, Ohashi-Kobayashi A, Maeda M.
Biol Pharm Bull. 2011;34(1):36-40.

Tissue and developmental expression of SRAM, an unconventional Rel-family protein.
Shiraishi H , Tanji T, Natori S, Ohashi-Kobayashi A.
Arch Insect Biochem Physiol. 2011 Jan;76(1):22-9.

Convergent synthesis of fluorescence-labeled probes of Annonaceous acetogenins and visualization of their cell distribution.
Kojima N, Morioka T, Urabe D, Yano M, Suga Y, Maezaki N, Ohashi-Kobayashi A, Fujimoto Y, Maeda M, Yamori T, Yoshimitsu T, Tanaka T.
Bioorg Med Chem. 2010 Dec 15;18(24):8630-41.

Heterodimers of NF-κB transcription factors DIF and Relish regulate antimicrobial peptide genes in Drosophila.
Tanji T, Yun EY, Ip YT.
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14715-20.

Functional analysis of the honeybee (Apis mellifera L.) salivary system using proteomics.
Fujita T, Kozuka-Hata H, Uno Y, Nishikori K, Morioka M, Oyama M, Kubo T.
Biochem Biophys Res Commun. 2010 Jul 9;397(4):740-4.

Morph-dependent expression and subcellular localization of host serine carboxypeptidase in bacteriocytes of the pea aphid associated with degradation of the endosymbiotic bacterium Buchnera.
Nishikori K, Kubo T, Morioka M.
Zoolog Sci. 2009 Jun;26(6):415-20.

Normal formation of a subset of intestinal granules in Caenorhabditis elegans requires ATP-binding cassette transporters HAF-4 and HAF-9, which are highly homologous to human lysosomal peptide transporter TAP-like.
Kawai H, Tanji T, Shiraishi H, Yamada M, Iijima R, Inoue T, Kezuka Y, Ohashi K, Yoshida Y, Tohyama K, Gengyo-Ando K, Mitani S, Arai H, Ohashi-Kobayashi A, Maeda M.
Mol Biol Cell. 2009 Jun;20(12):2979-90.

Age- and morph-dependent activation of the lysosomal system and Buchnera degradation in aphid endosymbiosis.
Nishikori K, Morioka K, Kubo T, Morioka M.
J Insect Physiol. 2009 Apr;55(4):351-7.

Functional dissection of transmembrane domains of human TAP-like (ABCB9).
Kamakura A, Fujimoto Y, Motohashi Y, Ohashi K, Ohashi-Kobayashi A, Maeda M.
Biochem Biophys Res Commun. 2008 Dec 19;377(3):847-51.

Differential activation of the lectin and antimicrobial peptide genes in Sarcophaga peregrina (the flesh fly).
Tanji T, Shiraishi H, Natori S, Ohashi-Kobayashi A.
Arch Insect Biochem Physiol. 2008 Dec;69(4):189-98.

Novel role of presenilins in maturation and transport of integrin β 1.
Zou K, Hosono T, Nakamura T, Shiraishi H, Maeda T, Komano H, Yanagisawa K, Michikawa M.
Biochemistry. 2008 Mar 18;47(11):3370-8.

Biochemical characterization of transporter associated with antigen processing (TAP)-like (ABCB9) expressed in insect cells.
Ohara T, Ohashi-Kobayashi A, Maeda M.
Biol Pharm Bull. 2008 Jan;31(1):1-5.

Cyclic AMP-dependent proteolysis of GATA-6 expressed on the intracellular membrane.
Tsuge T, Uetani K, Sato R, Ohashi-Kobayashi A, Maeda M.
Cell Biol Int. 2008 Feb;32(2):298-303.

A family of membrane proteins associated with presenilin expression and γ-secretase function.
Araki W, Takahashi-Sasaki N, Chui DH, Saito S, Takeda K, Shirotani K, Takahashi K, Murayama KS, Kametani F, Shiraishi H, Komano H, Tabira T.
FASEB J. 2008 Mar;22(3):819-27.

ABC transporter TAP-like and TAP family.
Maeda M, Ohashi-Kobayashi A.
Seikagaku. 2007 Jun;79(6):588-96.

Toll and IMD pathways synergistically activate an innate immune response in Drosophila melanogaster.
Tanji T, Hu X, Weber AN, Ip YT.
Mol Cell Biol. 2007 Jun;27(12):4578-88.

Interaction of Mat-8 (FXYD-3) with Na+/K+-ATPase in colorectal cancer cells.
Arimochi J, Ohashi-Kobayashi A, Maeda M.
Biol Pharm Bull. 2007 Apr;30(4):648-54.