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問209 クロラムフェニコールコハク酸エステルナトリウム

アプレピタントからホスアプレピタントが創製されたのと同様な目的で開発されたプロドラッグはどれか。1 つ選べ。


\put(-500,800){\text{\sffamily\bfseries 1}}
\sixheterov[b]
{6s==\sixheterov[]{4==\downnobond{N}{\raisebox{1mm}{H}};5s==\exodoublebond{0};6==\raisebox{-1mm}{O}}{2==(yl);5==H$\bf_3$C}[abcef];
2s==\pentamethylene{3==O;5==CH$\bf_3$}{1==(yl);2D==O}
}
{4Sd==\raisebox{1mm}{H};4Su==\put(-25,-35){\sixheterov[]{3==CH$\bf_3$;6==O;
5s==\trimethylenei{1==H$\bf_3$C}{3==(yl)}}{6==(yl)}[abf]};
5A==;5SB==\put(-35,-35){H};6SA==H;6SB==H$\bf_2$N}
[]
\put(220,200){\scalebox{0.5}{$\bullet$}\put(30,-25){\text{\sffamily\bfseries H$\bf_3$PO$\bf_4$}}}
\put(-900,-600){\text{オセルタミビルリン酸塩}}
\put(800,800){\text{\sffamily\bfseries 2}}
\hspace{6cm}
\sixheterov[bd,{B\FiveCycle(0,0){-18}[c]{4==N;
2s==\rotatebox{18}{\tetrahedral{1==(yl);3==\tetrahedral{1==(yl);3==\hexamethylene{2==O;5==O;
1s==\tetramethylenei{1==H$\bf_3$C}{2==CH$\bf_3$;3Sd==H$\bf_2$N;3Su==H;4==(yl)}}
{6==(yl);1D==O}}}};
2==N}
[e]}]{4==N;6==HN}{1D==O;5==H$\bf_2$N}[]
\put(220,200){\scalebox{0.5}{$\bullet$}\put(30,-25){\text{\sffamily\bfseries HCl}}}
\put(-1200,-600){\text{バラシクロビル塩酸塩}}
\\
\put(-2900,800){\text{\sffamily\bfseries 3}}
\put(-2900,400){
\sixheteroh[]
{5==O\raisebox{1mm}{\decaheterovb[]{4==O;9s==\put(-25,25){\exodoublebond{-60}};{{10}}==O;
2s==\sixheterov[bdf]
{5s==\decaheterovt[]{8==O\put(-80,35){\sixheteroh[]{1==H$\bf_3$C}{5==(yl)}[abcd]};
1==O;9==O;{10}s==\put(-25,40){\exodoublebond{-120}}
}{2==(yl)}[bcdefghk];
2s==\hexamethylene{4==\upnobond{N}{\raisebox{-0.8mm}{H}};
6s==\sixheterov[]{2==CH$\bf_3$;6==\raisebox{-0.8mm}{\lmoiety{HN}}}{1D==O;3==SCH$\bf_3$;5FA==H;5==(yl)}[be]
}{1==(yl);5D==O;6B==}
}
{1==(yl)}[f]
}
{5==(yl)}[afghijk]}}
{6==\lmoiety{H$\bf_3$C}}
[abcdf]
\put(100,-1000){\text{ドカルパミン}}
}
\\\\
\put(-3850,800){\textcolor{red}{\sffamily\bfseries 4}}
\put(-3750,-100){
\sixheterov[bdf]
{2s==\heptamethylene{4==\upnobond{N}{H};7==Cl}{1==(yl);2Sd==H;2Su==OH;5D==O;6==Cl;3SB==H;
3SA==\tetrahedral{1==(yl);3==\tetrahedral{1==(yl);
0==O\pentamethylenei{5==COONa}{1==(yl);2D==O}}}}}
{5==O$\bf_2$N}[]
\put(-500,-300){\text{クロラムフェニコールコハク酸}}
\put(-250,-400){\text{エステルナトリウム}}
}
\put(-1450,800){\text{\sffamily\bfseries 5}}
\put(-1350,-100){
\decaheterov
[acK,{G\FiveCycle(-63,-10){180}[]{4s==\carbonylrotate{0}}[]}]
{2s==\trimethylene{3==COONa}{1==(yl);2==CH$\bf_3$}}
{}[ghi]
\put(-1100,-300){\text{ロキソプロフェンナトリウム}}
}